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Novel method developed by HKBU scholars could help produce purer, safer drugs The technique, which is a world-first breakthrough, uses a specific nanomaterial layer to detect the target molecules in pharmaceuticals and pesticides in just five minutes.
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- Novel method developed by HKBU scholars could help produce purer, safer drugs
The new HKBU invention can be applied to the drug discovery process, as well as the production and quality control stages of pharmaceutical manufacturing. It can also be used in environmental monitoring.
Optical activity of molecules is amplified in more than 10 folds, by structure-specific adsorption of the molecules on chiral nanoparticles. Normally each molecule has two "chiral" versions which are mirror images of each other in terms of absolute configuration.
While otherwise identical, these "right-handed" and "left-handed" molecules can have totally different effects. For example, anti-inflammatory drug naproxen of a particular type of chirality can treat arthritis pain while its mirror image twin can result in liver poisoning.
As a result, selecting only useful chiral molecules during the drug discovery process can help produce pure drugs that can cure specific diseases with no adverse effects.
However, producing pure drugs is very expensive and time consuming.
Current medicinal drugs are often made up of equal amounts of the left- and right-handed chiral molecules in what is known as a racemic mixture. While this fifty-fifty split single reis winterberg low production cost, it also single reis winterberg single party münchen freiheitshalle lower overall efficacy and, in some cases, can lead to toxic side effects in the human body.
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According to Dr Jeffery Huang, sensitively identifying and locating the correct form of a chiral molecule during the drug discovery process is essential, but is currently difficult and time-consuming because molecules are typically too small to be sensitively monitored.
However, the specific nanomaterial designed and synthesised by the team, which is composed of silver chiral nanoparticles, can "amplify" the signal of the desired chiral molecules and improve detection sensitivity by more than fold, making the location process faster, more accurate and less expensive.
Dr Huang single reis winterberg that this work opens a new door for material scientists to apply these metallic chiral nanoparticles to drug production processes, as currently there are a limited number of nanomaterial fabrication techniques on offer. He said: The ability of the chiral nanoparticles to amplify the detection sensitivity is practically desired for trace detection.
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The novel nanomaterial developed by the team will eventually provide a new platform for efficiently and effectively detecting the chiroptical purity of synthesised compounds, and will help to produce drugs without side effects. It is also a new breakthrough in the resolution of racemic drugs, he added.